The World Health Organization defines depression as a primary contributor to the global burden of disease and predicts it will become the second leading cause of death by 2020. The need to develop effective therapies has never been so pressing. Current antidepressant drugs have several limitations. This 2010 book looks at the future of mood-disorder research, covering the identification of new therapeutic targets, establishing new preclinical models, new medicinal chemistry opportunities, and fostering greater understanding of genetic influences. These strategies are likely to help build a better picture of the disease process, and lead to new opportunities for patient stratification and treatment. The ultimate goal for this strand of research is to develop more personalized and effective treatments for this chronic and debilitating condition. This is essential reading for all those involved in psychopharmacologic drug development, and mental health clinicians seeking a preview of disc
Analyzing a key cause of infectious morbidity in immunosuppressed and immunocompromised patients, this source spans the most recent strategies to improve and expedite the diagnosis, identification, an
How do violent jihadists use language to try to persuade people to carry out violent acts? This book analyses over two million words of texts produced by violent jihadists to identify and examine the linguistic strategies employed. Taking a mixed methods approach, the authors combine quantitative methods from corpus linguistics, which allows the identification of frequent words and phrases, alongside close reading of texts via discourse analysis. The analysis compares language use across three sets of texts: those which advocate violence, those which take a hostile but non-violent standpoint, and those which take a moderate perspective, identifying the different uses of language associated with different stages of radicalization. The book also discusses how strategies including use of Arabic, romanisation, formal English, quotation, metaphor, dehumanisation and collectivisation are used to create in- and out-groups and justify violence.
How do violent jihadists use language to try to persuade people to carry out violent acts? This book analyses over two million words of texts produced by violent jihadists to identify and examine the linguistic strategies employed. Taking a mixed methods approach, the authors combine quantitative methods from corpus linguistics, which allows the identification of frequent words and phrases, alongside close reading of texts via discourse analysis. The analysis compares language use across three sets of texts: those which advocate violence, those which take a hostile but non-violent standpoint, and those which take a moderate perspective, identifying the different uses of language associated with different stages of radicalization. The book also discusses how strategies including use of Arabic, romanisation, formal English, quotation, metaphor, dehumanisation and collectivisation are used to create in- and out-groups and justify violence.
"Each year more than 4 million hunters pursue waterfowl species in North America alone. This basic outdoor reference for hunters covers bird identification and actual hunting strategies for 2
This book covers the most important issues from classical and robust control, deterministic and stochastic control, system identification, and adaptive and iterative control strategies. It covers most
The author of the audiobook The Wisdom of the Breath explains the source of human suffering--identification with a solid sense of self--and offers strategies for dispelling this source of suffering. O
Miniature Lives provides a range of simple strategies that people can use to identify and learn more about the insects in their homes and gardens. Featuring a step-by-step, illustrated identification
Numerical Methods in Finance has emerged as a discipline at the intersection of probability theory, finance and numerical analysis. This book, based on lectures given at the Newton Institute as part of a broader programme, describes a wide variety of numerical methods used in financial analysis: computation of option prices, especially of American option prices, by finite difference and other methods; numerical solution of portfolio management strategies; statistical procedures; identification of models; Monte Carlo methods; and numerical implications of stochastic volatilities. Articles have been written in a pedagogic style and made reasonably self-contained, covering both mathematical matters and practical issues in numerical problems. Thus the book has something to offer economists, probabilists and applied mathematicians working in finance.
Although the phenomenon of ADHD (Attention-Deficit Hyperactivity Disorder) is well described in children, it is now thought that in up to 60% of cases the symptoms persist into adulthood. This volume reviews our growing knowledge of adult ADHD and presents a transatlantic perspective on the identification, assessment and treatment of the disorder. The introductory section covers the history of ADHD, as well as the epidemiology, consequences, gender differences and legal aspects. Detailed descriptions of the clinical features of ADHD in adults are then given to enhance the reader's clinical recognition and assessment. Subsequent sections cover treatment strategies, emphasising pharmacological, psychological and social interventions. Written and edited by experts internationally renowned for their work in ADHD, this is an essential resource for all mental health workers who encounter adults presenting with neurodevelopmental disorders.
Rapid advances in computational methods and computer capabilities have led to a new generation of structural identification strategies. Robust and efficient methods have successfully been developed on
This is an introductory text for students interested in identification and analysis of animal remains from archaeological sites. The emphasis is on animals whose remains inform us about the relationship between humans and their natural and social environments, especially site formation processes, subsistence strategies, the processes of domestication, and paleoenvironments. Examining examples from all over the world, from the Pleistocene period up to the present, this volume is organized in a way that is parallel to faunal study, beginning with background information, bias in a faunal assemblage, and basic zooarchaeological methods. This revised edition reflects developments in zooarchaeology during the past decade. It includes sections on enamel ultrastructure and incremental analysis, stable isotyopes and trace elements, ancient genetics and enzymes, environmental reconstruction, people as agents of environmental change, applications of zooarchaeology in animal conservation and herit
This is an introductory text for students interested in identification and analysis of animal remains from archaeological sites. The emphasis is on animals whose remains inform us about the relationship between humans and their natural and social environments, especially site formation processes, subsistence strategies, the processes of domestication, and paleoenvironments. Examining examples from all over the world, from the Pleistocene period up to the present, this volume is organized in a way that is parallel to faunal study, beginning with background information, bias in a faunal assemblage, and basic zooarchaeological methods. This revised edition reflects developments in zooarchaeology during the past decade. It includes sections on enamel ultrastructure and incremental analysis, stable isotyopes and trace elements, ancient genetics and enzymes, environmental reconstruction, people as agents of environmental change, applications of zooarchaeology in animal conservation and herit
Infertility Counseling: A Comprehensive Handbook for Clinicians, 2nd edition, is a comprehensive, multidisciplinary textbook for all health professionals providing care for individuals facing reproductive health issues. It is the most thorough and extensive book currently available for clinicians in the field of infertility counseling, providing an exhaustive and comprehensive review of topics. It addresses both the medical and psychological aspects of infertility, reviewing assessment approaches, treatment strategies, counseling for medical conditions impacting fertility, third-party reproduction, alternative family building and post infertility counseling issues. Each chapter follows the same format: introduction, historical overview, literature review, theoretical framework, identification of clinical issues, suggestions for therapeutic interventions, and future implication. This edition also includes extensive appendixes of clinical tools useful to the clinician, including an Inter
This concise overview of the fundamental concepts of cancer biology is ideal for those with little or no background in the field. A summary of global cancer patterns introduces students to the general principles of how cancers arise and the risk factors involved. By focusing on fundamental examples of the signalling pathways within cells, the functional effects of DNA damage are explained. Later chapters then build on this foundation to provide a comprehensive summary of the major signalling pathways that affect tumour development. Current therapeutic strategies are reviewed, along with a discussion of methods for tumour detection and biomarker identification. Finally, the impact of whole genome sequencing is discussed, bringing students up to date with key recent developments in the field. From basic principles to insights into cutting-edge research, this book will enable the reader to move into the cancer field with confidence.
Infertility Counseling: A Comprehensive Handbook for Clinicians, 2nd edition, is a comprehensive, multidisciplinary textbook for all health professionals providing care for individuals facing reproductive health issues. It is the most thorough and extensive book currently available for clinicians in the field of infertility counseling, providing an exhaustive and comprehensive review of topics. It addresses both the medical and psychological aspects of infertility, reviewing assessment approaches, treatment strategies, counseling for medical conditions impacting fertility, third-party reproduction, alternative family building and post infertility counseling issues. Each chapter follows the same format: introduction, historical overview, literature review, theoretical framework, identification of clinical issues, suggestions for therapeutic interventions, and future implication. This edition also includes extensive appendixes of clinical tools useful to the clinician, including an Inter
Numerical Methods in Finance has emerged as a discipline at the intersection of probability theory, finance and numerical analysis. This book, based on lectures given at the Newton Institute as part of a broader programme, describes a wide variety of numerical methods used in financial analysis: computation of option prices, especially of American option prices, by finite difference and other methods; numerical solution of portfolio management strategies; statistical procedures; identification of models; Monte Carlo methods; and numerical implications of stochastic volatilities. Articles have been written in a pedagogic style and made reasonably self-contained, covering both mathematical matters and practical issues in numerical problems. Thus the book has something to offer economists, probabilists and applied mathematicians working in finance.
This book, published in the late 1980s, reproduces articles and reports which were written and gained prominence during the 1984–5 coal dispute in the UK. It is, however, more than a contribution to the history of that dispute and the associated debates about the viability and strategies of the NCB (now British Coal) and its constituent pits. The collection addresses more general issues of industrial and national policy and concerns about the interface of accountancy and economic calculation in industrial relations. The contributions offer contrasting approached to the identification and measurement of enterprise performance, including the value of accounting reports, the assessment of strategies to invest in new technology, the costs and benefits of alternative energy policies and the distinction between the national and enterprise interests. In addition, the editors' introduction and the authors' postscripts consider the contributions of these debates in relation to the progress and
Theological interpretation of the Bible is one of the most significant debates within theology today. Yet what exactly is theological reading? Darren Sarisky proposes that it requires identification of the reader via a theological anthropology; an understanding of the text as a collection of signs; and reading the text with a view toward engaging with what it says of transcendence. Accounts of theological reading do not often give explicit focus to the place of the reader, but this work seeks to redress this neglect. Sarisky examines Augustine's approach to the Bible and how his theological insights into the reader and the text generate an aim for interpretation, which is fulfilled by fitting reading strategies. He also engages with Spinoza, showing that theological exegesis contrasts not with approaches that take history seriously, but with naturalistic approaches to reading.
Theological interpretation of the Bible is one of the most significant debates within theology today. Yet what exactly is theological reading? Darren Sarisky proposes that it requires identification of the reader via a theological anthropology; an understanding of the text as a collection of signs; and reading the text with a view toward engaging with what it says of transcendence. Accounts of theological reading do not often give explicit focus to the place of the reader, but this work seeks to redress this neglect. Sarisky examines Augustine's approach to the Bible and how his theological insights into the reader and the text generate an aim for interpretation, which is fulfilled by fitting reading strategies. He also engages with Spinoza, showing that theological exegesis contrasts not with approaches that take history seriously, but with naturalistic approaches to reading.
