Two types of cholinesterases (ChEs) are found in the mammalian brain: acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). They are products of two different genes and exhibit different loca
The cholinergic system has been recognized as playing an important role not only in several forms of dementia besides Alzheimer's Disease, but also in other CNS degenerative and psychiatric disorders.
Since the apoE4 allele is a risk factor or susceptibility gene in late-onset familial and sporadic AD, the mechanism of disease expression may involve metabolic effects that are isoform specific. Isof
