陳振炎博士回憶錄（國際英文版）

本書是美籍台人知名國際生技醫學家陳振炎博士的英文自傳。這位來自台中的台灣囡仔，出生於1940 年代日據時代，幼年四歲喪母，爾後經歷病痛、貧困、戰爭，看遍人生百態，在窮困中的年代卻積極奮鬥；在東海大學結識了相知一生的靈魂伴侶──後來成為陳夫人的陳阮明珠（Pearl Chen），兩人秉持著對生物醫學的喜愛，開啟了一生亦師亦友的人生樂章。陳振炎博士台大醫學院畢業後，取得美國北卡羅來納大學教堂山分校（UNC）醫學院深造的機會，夫妻倆在美國生醫界取得許多重要的生物醫學專利，兩人在世界一流的醫學研究機構──美國國立衛生研究院 （NIH）──與頂尖的醫生和研究人員一起工作，以改善人類健康，創造福祉為己任。

“Game Changer”一詞來自一個科學實驗。如果一項實驗不起作用，則重新設計實驗並再次進行，直到實驗有效。實驗中的變化可以說是“改變遊戲規則”。就像中國的老諺語：“天助自助者也！”

""Life for a young Taiwanese boy growing up in a Japanese-controlled country in the 1940s was not easy. He was certainly not born with a silver spoon in his mouth. At a vulnerable age of only four, he would lose his mother to a skin infection that in today’s world would have been easily treated with a trip to the doctor’s office. War, poverty, and the daily struggle to survive would set the stage for a real life Cinderella story complete with a harsh stepmother, a fairy godmother, and a beautiful princess who would transform his world.

This is the awe-inspiring life story of Dr. Michael Cheng-Yien Chen, a man who was able to endure the hardships of loss, poverty, and war to discover his gift of academic excellence, find his soulmate, and pursue the American dream. Dr. Chen’s work ethic comes from the poor environment he grew up in and from his experiences struggling to promote himself and his career. His American Dream starts from his campus life in the University of North Carolina at Chapel Hill (UNC), and prospers on his career life in National Institutes of Health (NIH) - a world-class medical research institute where top doctors and researchers work together to improve human health.

The phrase “Game Changer” comes from a scientific experiment. If one experiment does not work, then redesign the experiment and do it again until the experiment works. The changes in the experiment are what “Changes the Game” so to speak. Just like the old Chinese proverb: “God will help a person who helps himself first!”""

My life story is one of a first-generation immigrant who left Taiwan for further education and a new life in the United States. Naturally, my grandchildren are interested in understanding how their grandparents came from a country so different from the United States, the country of birth for all of my grandchildren. In addition, they want to know how their grandparents adapted to life in the US and built successful careers. This is my opportunity to write the story of my childhood, education, immigration and later life, so that my children, grandchildren, and future generations will have a better understanding of their roots. It is also an important occasion to impart some of my advice and perspective on how they can be successful individuals and members of the world in which they live.

The writing of this story happens to coincide with my fiftieth wedding anniversary, March 8, 2014. I dedicate this story to my wife, Pearl, my other half. We have lived and worked together for so many years to raise a family and make our dreams become a reality. Stories are always winners because stories are the glue that holds families together. The best way to connect with children and grandchildren is by telling stories.

My life started with a lot of hardship and I struggled to adapt to the difficult environment. I overcame the hardship and my story ends happily. I’d like to share some of my advice to give my future generations guidance and inspiration.

―Michael Cheng-Yien Chen, PhD


▲Michael C. Chen Professional Experience and Recognition▲

Vice President SynAm Vaccine Inc. Gaithersburg, MD 2006-2011
Senior Scientist- Kelly Services National Institute of Health, NIH Bethesda, MD 2004-2006
Vice President SynAm Vaccine Inc. Rockville, MD 2000-2004
Senior Scientist-SAIC Services National Cancer Institute, NIH Frederick, MD 2001-2003
Senior Scientist EpiGenesis Pharmaceuticals Inc. Cranberry, NJ 1998-1999
Patent Examiner Patent and Trademark Office Crystal City VA 1996-1997
Expert/ Special Expert National Cancer Institute NIH Bethesda, MD 1991-1996
Research Associate Professor Uniformed Service University of the Health Sciences Bethesda, MD 1990-1991
Vice President/ Senior Vice President America BioTechnology Inc. Cambridge, MA 1988-1990
Senior Scientist, Imclone Inc. NY 1987-1988
Section Head, BioTechnica International Inc. Cambridge, MA 1983-1987
Senior Scientist, Abbott Laboratories, Abbott Park, Illinois 1977-1980
Fellow, Staff Fellow, Senior Staff Fellow, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 1972-1977
Doctor of Philosophy, Medical School, University of North Carolina at Chapel Hill, NC 1968-1972
Instructor, Department of Bacteriology, Taipei Medical University, Taipei, Taiwan 1967-1968
Master of Medicine, School of Medicine, National Taiwan University, Taipei, Taiwan 1965-1967
Teaching Assistant, Department of Bacteriology, Taipei Medical University, Taipei, Taiwan 1963-1965
Second Lieutenant, Taichung Second Army Training Center, Taichung, Taiwan 1962-1963
Bachelor of Science, College of Science, Tunghai University, Taichung, Taiwan 1958-1962

▲Michael C. Chen Patents▲

Canada Patent No. 2504938 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2011
Australian Patent No. 2003291365 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2009
US Patent No. 7,585,669 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2009
Taiwan Patent No. 92131025 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2009
China Patent No. ZL 200380102758.6 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2008
US Patent No.7,217,791 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2007
Singapore Patent No.112211 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2007
International Publication Number WO 2004/043376 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2004
US Patent No. 5,422,267 R.R. Yocum, R.S. Daves, and M.C. Chen. Industrial yeast comprising an integrated glucoamylase gene, 1995
Canadian Patent No. 1,316,472 R.R. Yocum, R.S. Daves, and M.C. Chen. Yeast expressing glucoamylase, 1993
Canadian Patent No. 1,282,357 M.C. Chen, P.C. Chen and L.C. Klotz. Detection of human cells by nucleic acid hybridization, 1991
European Patent Publication No. 003787B1 P.P Hung, S.G. Lee, R. Roychoudhury, B.J. Ratzkin, M.C. Chen and W.J. Shrenk. Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom, 1991
US Patent No. 4,866,167 M.C. Chen, P.C. Chen, and L.C. Klotz. Detection of human oral cells by nucleic acid hybridization, 1989
European Patent Application No. 86903851.3 R.R. Yocum, R. Daves, and M.C. Chen. Yeast expressing glucoamylase, 1987
European Patent Publication No. 0199439A1 M.C. Chen and L.C. Klotz. A method and probe for the detection of cells associated with human oral medical disorders or with healthy human gingiva, 1986
International Patent Publication No. WO86107091 R.R. Yocum, R.S. Daves and M.C. Chen. Yeast expressing glucoamylase, 1986
US Patent No. 4,370,417 P.P. Hung, S.G. Lee, R. Roychoudhury, B. Ratzkin, W. J. Schrenk and M.C. Chen. Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom, 1983
US Patent No. 452,345 M.C. Chen and B.R. Snedecor. Production of rennin and its natural precursors using recombinant DNA techniques, 1982
US Patent No. 159,315 M.C. Chen, S.G. Lee and P.P. Hung. Method of isolating messenger RNA specific for urokinase plasminogen activator using immunoprecipitation procedures, 1981

▲Michael C. Chen Publication▲

Chen, D-S. Chen, M., Huo, L., Zho, S., Wu, E., Tsiomenko., A., and Chen, S. A new single protein as a vaccine with broad effects for prevention of pneumococcal infection. Pneumococcus and Respiratory Syncytial Virus, BIT Life Sciences 2nd World Congress of Vaccine, March 24-26, 2010
Bert Gold, Francis Kalush, Julie Bergeron, Kevin Scott, Nandita Mitra, Kelly Wilson, Nathan Ellis, Helen Huang, Michael Chen, Ross Lippert, Bjarni V. Halldorsson, Beth Woodworth, Thomas White, Andrew G. Clark, Fritz F. Parl, Samuel Broder, Michael Dean, and Kenneth Offit. Estrogen receptor genotyping and haplotypes associated with breast cancer risk. Cancer Research 64:8891-8900, 2004
Chou, C-J., Li, Z., Chen M-L., Chen, M.C, Chen, D-S., and Wu, M-C Immunization of mice with pneumococcal conjugate vaccine using mutant pneumolysin protein carrier against streptococcus pneumonia. Protein-based pneumococcal vaccines PROT-6 2004
Joseph A. DiPaolo, Michael Chen, Zwi N. Bornean, A Gazing-Demo, and P. Lusso. Synergistic transactivation of the HIV-1 LTR in genital epithelial cells by HHV-6 genomic fragments and TAT-1. J. Med. Virol. 50: 20-24, 1996
DiPaolo, J.A., Chen, M.C., Popescu, N.C., Woodworth, C.D., Zimonjic, D.B. Interrelationship of human papillomavirus, human herpesvirus, and human immunodeficiency virus. In: Monsonego, J., ed. Papillomavirus in human pathology. Rome: Serono Symposia Publications, 55-63, 1995
Chen, M., Wang, H., Berneman, Z., and Lusso, P., Ablashi, D.V., and DiPaolo, J.A. Detection of human herpesvirus (HHV-6) and human papillomavirus-16 in cervical carcinoma. J. Amer. Pathol. 145:1509, 1994
Wang, H., Chen M.C., Berneman Z.N., and DiPaolo J.A. Detection of human herpesvirus-6 in paraffin embedded tissue of cervical cancer by polymerase chain reaction. J. Virol. Methods. 47:297-305, 1994
Chen, M., Popescu N., Woolworth, C., Berneman, Z., Lusso, P., Ablashi, D.V., and DiPaolo, J.A. Human Herpesvirus-6 infects cervical epithelial cells and transactivates human papillomavirus gene expression. J. Virol. 68: 1173-1178, 1994
Popescu, N., Chen, M., Simpson, S., Solinas, S., and DiPaolo, J.A. A Burkitt lymphoma cell line with integrated Epstein-Barr virusat a stable chromosome modification site. Viral. 195: 248-251, 1993
DiPaolo, J.A., Popescu, M, M., Zimonjic, D., Bornean, Z., and Lusso, P. Interaction of human papillomavirus (HPV) and HIV-1 in HPV-immortalized or tumorigenic cervical cells. Proc. Amer. Assoc. For Cancer Research 34:543, 1993
Zhang, X., Hernandez, M.R., Chen, M.C, and Erickson-Lamy, K.A. Further characterization of muscarinic receptor subtype mRNA in the human ciliary muscle. Investigative Ophthal. And Visual Sci. 32:1200, 1992
Colombian, S., Ablashi, D., Chen, M., DiPaolo, J., Biberfeld, P., and Gallo, R. A new simian herpesvirus contributes substantially to the establishment of B-cell lymphoma in immunodeficiency monkey. Vth International Symposium on Epstein-Barr virus and Associated Diseases VI: 21, 1992
DiPaolo, J.A., Chen, M.C., Corbellino, M., and Ablashi, D.V. Human herpes virus (HHV-6) increases expression of human papilloma (HPV) genes in malignant and non-malignant cervical cells. proc. Amer. Assoc. for Cancer Research 33:392, 1992
Chen, M., Popescu, N., Woolworth, C., Berneman, A., Corbellino, M., Lusso, P., Ablashi, D.V., and DiPaolo, J.A. relationship of human papilloma virus and human herpes virus 6 to cervical neoplasia. The third meeting on the molecular basis of human cancer 51, 1992
Erickson-Lamy, K.A., Chen, M.C. and Hernandez., M.R. Expression of muscarinic receptor mRNA in cultured ciliary muscle cells. Investigative Ophthal. And Visual Sci. 32:833, 1991
French, C.K., Simon, S.L., Chen, M.C., Ekland, S.M., Klotz,. L.C., Vaccaro, K.K., and Savitt, E.D. DNA Probe Diagnosis ofPeriodontal Disease, Chapter 10, 241-263 in Nucleic Acid and Monoclonal Antibody Probes, Application in Diagnostic Microbiology. Maecell Dekker, Inc. New York, 1989
French, C.K., Savitt, E.D., Simon, S.L., Eklund, S.M., Chen, M.C., Klotz, L.C., and Vaccaro, KK. DNA probe detection of periodontal pathogens. Oral microbiology And Immunol. 1:58-62, 1986
Savitt, E.D., Chen, M.C., Vaccaro, K.K., Dzink, J., Chen, P., and Eklund, S.L. Detection of A. Actinomycetemcomitans in plaque by RNA probes. J. Dental Research 65:1648, 1986
Chen, M.C., Chen, P., and Klutz, L.C. use of DNA and RNA probes for the detection of pathogenic bacteria in human oral diseases. Amer. Soc. Microbiol. 86:95, 1986
Ratzkin, B., Lee, S.G., Schlenk, W.J., Roychoudhury, R., Chen, M.C., Hamilton, T.A., and Hung, P.P. Expression in E.coli of biologically active enzyme by a DNA sequence coding for human plasminogen activator, urokinase. Proc. Natl Acad. Sci. (USA) 78:3313-3317, 1981
Lee, S.G., Stowell, C., Hoppe, C., See, Y.S., Chan, S.K., Chen, M.C., and Hung, P.P. Biochemical characterization of urokinase from human fetal kidney cells. In Progress in Fibrinolysis. Volume V, Chapter VI 38-43, 1981
Chen, M.C., Lebowitz, J., and Salzman, N.P. Hind D restriction mapping of unpaired regions in Simian virus 40 superhelical DNA I: consideration regarding structure-function relationships. J. Virol. 18:211-217, 1976
Leibowitz, J., Garon, C.F., Chen, M.C., and Salzman, N.P. chemical modification of Simian virus 40 DNA by reaction with water soluble carbodiimide. J. Virol. 18: 205-210, 1976
Chen, M.C., Berkenmeier, E., and Salzman, N.P. Simian virus 40 DNA replication: characterization of a gap at the DNA termination site. Cold Spring Harbor Tumor Virus Symposia 37, 1975
Kito, G., Chaudhuri, K., Gonenne, A., Chen, M.C., and Lebowitz, J. Characterization of chemical modification of superhelical PM 2 DNA I with MC carbodiimide. Biophysical J. 15:96, 1975
Chen, M.C., Chang, K.S., and Salzman, N.P., Studies of polyoma virus DNA: cleavage map of polyoma virus genome. J. Virol.15:191-198, 1975
Salzman, N.P., Lebowitz, J., Chen, M.C., Kasselberg, A.G., and Garon, C.F. Properties of SV 40 DNA molecules and mapping unpaired regions in SV 40 DNA I. Symposia on Quantitative Biology 39:209-218, 1974
Chen, M.C., Hutchinson III, C.A., and Edgell M.H. Isolation and genetic localization of three Phi X 174 promoter regions. Nature New Biology 243_233-236, 1973
Chen, M.C., Bacteriophage Phi X 174: Genetic recombination, direction of DNA synthesis and localization of promoters. Ph.D. Dissertation. University of North Carolina at Chapel Hill, School of Medicine, 1972
Chen M.C., Hutchinson III, C.A., and Edgell, m.H. In vitro synthesis of infective Phi X 174 recombinant DNA. Cold Spring Harbor Bacteriophage Symposia 106, 1971
Chen, M.C. Dual infection of Simian virus 40 and human adenovirus type 12 in Taiwan monkey kidney cell. Master of Science Thesis. National Taiwan University, School of Medicine, 1967
Hsieh, H.C., Chen, M.C., and Lin, F.M. Studies of the chronic infection of Salmonella typhimurium in mice. J. Formosan Med. Assoc. 63:598, 1964
Liao, T.H. Hsieh, H.C., Chen, M.C. Studies on the isolation of thiamine decomposing bacteria. I. On the aerobic thiamine decomposing bacteria isolated from Taiwan. J. Formosan Med. Assoc. 63:595, 1963

▲Michael C. Chen Books▲

Nucleic acid and monoclonal antibody Probes, Applications in Diagnostic Microbiology Published by Marcel Dekker, Inc, New Yorkand Basel, 1989 Edited by Bala Swaminathan, Gyan Prakash In Chapter 10: DNA Probe Diagnosis of Periodontal Disease.
Cynthia K French, Susanne L Simon, Michael C. Chen, Suzanne M. Eklund, Lynn C Klotz and Karen K. Vaccaro.
Progress in Fibrinolysis. Volume V, 1981 Biochemical characterization of urokinase from human fetal kidney cells. Lee, S.G.,
Stowell,C, Hoppe, C, See,Y.S, Chan, S.K., Chen, M.C. and Hung, P.P

▲Michael C. Chen Sports Achievements▲

Michael C. Chen Washington Area Chinese Tennis Association (WACTA) Tournament
1994 Men’s 3.5 level Single 1st place
1994 Men’s Double C group 1st place
1995 Men’s 4.0 level Single 1st place
1995 Men’s 4.0 level Double 1st place
1997 Men’s 4.0 level Double 1st place
1998 Men’s 4.0 level Double 1st place
1999 Men’s 4.0 level Double 1st place
2004 Men’s 4.0 level Double 1st place

Michael Chen Gaithersburg City Senior Open Tennis Tournament
2001 Mix Double 1st place
2002 Mix Double 1st place

Michael C Chen US Eastern Region Taiwanese Softball Association
1974 Softball Tournament at Washington DC 1st place
1975 Softball Tournament at New Jersey 1st place
1976 Softball Tournament at New York City 1st place

▲Michael C. Chen Professional Experience and Recognition▲

Vice President SynAm Vaccine Inc. Gaithersburg, MD 2006-2011
Senior Scientist- Kelly Services National Institute of Health, NIH Bethesda, MD 2004-2006
Vice President SynAm Vaccine Inc. Rockville, MD 2000-2004
Senior Scientist-SAIC Services National Cancer Institute, NIH Frederick, MD 2001-2003
Senior Scientist EpiGenesis Pharmaceuticals Inc. Cranberry, NJ 1998-1999
Patent Examiner Patent and Trademark Office Crystal City VA 1996-1997
Expert/ Special Expert National Cancer Institute NIH Bethesda, MD 1991-1996
Research Associate Professor Uniformed Service University of the Health Sciences Bethesda, MD 1990-1991
Vice President/ Senior Vice President America BioTechnology Inc. Cambridge, MA 1988-1990
Senior Scientist, Imclone Inc. NY 1987-1988
Section Head, BioTechnica International Inc. Cambridge, MA 1983-1987
Senior Scientist, Abbott Laboratories, Abbott Park, Illinois 1977-1980
Fellow, Staff Fellow, Senior Staff Fellow, National Institute of Allergy and Infectious Diseases, National Institute of Health, Bethesda, MD 1972-1977
Doctor of Philosophy, Medical School, University of North Carolina at Chapel Hill, NC 1968-1972
Instructor, Department of Bacteriology, Taipei Medical University, Taipei, Taiwan 1967-1968
Master of Medicine, School of Medicine, National Taiwan University, Taipei, Taiwan 1965-1967
Teaching Assistant, Department of Bacteriology, Taipei Medical University, Taipei, Taiwan 1963-1965
Second Lieutenant, Taichung Second Army Training Center, Taichung, Taiwan 1962-1963
Bachelor of Science, College of Science, Tunghai University, Taichung, Taiwan 1958-1962

▲Michael C. Chen Patents▲

Canada Patent No. 2504938 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2011
Australian Patent No. 2003291365 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2009
US Patent No. 7,585,669 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2009
Taiwan Patent No. 92131025 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2009
China Patent No. ZL 200380102758.6 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2008
US Patent No.7,217,791 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2007
Singapore Patent No.112211 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2007
International Publication Number WO 2004/043376 Chen, Michael C., Chiou, Chuang-Jiun, Li., Zhongming, and Chen, Dong-Sheng. Compositions and methods for treating or preventing pneumococcal infection, 2004
US Patent No. 5,422,267 R.R. Yocum, R.S. Daves, and M.C. Chen. Industrial yeast comprising an integrated glucoamylase gene, 1995
Canadian Patent No. 1,316,472 R.R. Yocum, R.S. Daves, and M.C. Chen. Yeast expressing glucoamylase, 1993
Canadian Patent No. 1,282,357 M.C. Chen, P.C. Chen and L.C. Klotz. Detection of human cells by nucleic acid hybridization, 1991
European Patent Publication No. 003787B1 P.P Hung, S.G. Lee, R. Roychoudhury, B.J. Ratzkin, M.C. Chen and W.J. Shrenk. Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom, 1991
US Patent No. 4,866,167 M.C. Chen, P.C. Chen, and L.C. Klotz. Detection of human oral cells by nucleic acid hybridization, 1989
European Patent Application No. 86903851.3 R.R. Yocum, R. Daves, and M.C. Chen. Yeast expressing glucoamylase, 1987
European Patent Publication No. 0199439A1 M.C. Chen and L.C. Klotz. A method and probe for the detection of cells associated with human oral medical disorders or with healthy human gingiva, 1986
International Patent Publication No. WO86107091 R.R. Yocum, R.S. Daves and M.C. Chen. Yeast expressing glucoamylase, 1986
US Patent No. 4,370,417 P.P. Hung, S.G. Lee, R. Roychoudhury, B. Ratzkin, W. J. Schrenk and M.C. Chen. Recombinant deoxyribonucleic acid which codes for plasminogen activator and method of making plasminogen activator protein therefrom, 1983
US Patent No. 452,345 M.C. Chen and B.R. Snedecor. Production of rennin and its natural precursors using recombinant DNA techniques, 1982
US Patent No. 159,315 M.C. Chen, S.G. Lee and P.P. Hung. Method of isolating messenger RNA specific for urokinase plasminogen activator using immunoprecipitation procedures, 1981

▲Michael C. Chen Publication▲

Chen, D-S. Chen, M., Huo, L., Zho, S., Wu, E., Tsiomenko., A., and Chen, S. A new single protein as a vaccine with broad effects for prevention of pneumococcal infection. Pneumococcus and Respiratory Syncytial Virus, BIT Life Sciences 2nd World Congress of Vaccine, March 24-26, 2010
Bert Gold, Francis Kalush, Julie Bergeron, Kevin Scott, Nandita Mitra, Kelly Wilson, Nathan Ellis, Helen Huang, Michael Chen, Ross Lippert, Bjarni V. Halldorsson, Beth Woodworth, Thomas White, Andrew G. Clark, Fritz F. Parl, Samuel Broder, Michael Dean, and Kenneth Offit. Estrogen receptor genotyping and haplotypes associated with breast cancer risk. Cancer Research 64:8891-8900, 2004
Chou, C-J., Li, Z., Chen M-L., Chen, M.C, Chen, D-S., and Wu, M-C Immunization of mice with pneumococcal conjugate vaccine using mutant pneumolysin protein carrier against streptococcus pneumonia. Protein-based pneumococcal vaccines PROT-6 2004
Joseph A. DiPaolo, Michael Chen, Zwi N. Bornean, A Gazing-Demo, and P. Lusso. Synergistic transactivation of the HIV-1 LTR in genital epithelial cells by HHV-6 genomic fragments and TAT-1. J. Med. Virol. 50: 20-24, 1996
DiPaolo, J.A., Chen, M.C., Popescu, N.C., Woodworth, C.D., Zimonjic, D.B. Interrelationship of human papillomavirus, human herpesvirus, and human immunodeficiency virus. In: Monsonego, J., ed. Papillomavirus in human pathology. Rome: Serono Symposia Publications, 55-63, 1995
Chen, M., Wang, H., Berneman, Z., and Lusso, P., Ablashi, D.V., and DiPaolo, J.A. Detection of human herpesvirus (HHV-6) and human papillomavirus-16 in cervical carcinoma. J. Amer. Pathol. 145:1509, 1994
Wang, H., Chen M.C., Berneman Z.N., and DiPaolo J.A. Detection of human herpesvirus-6 in paraffin embedded tissue of cervical cancer by polymerase chain reaction. J. Virol. Methods. 47:297-305, 1994
Chen, M., Popescu N., Woolworth, C., Berneman, Z., Lusso, P., Ablashi, D.V., and DiPaolo, J.A. Human Herpesvirus-6 infects cervical epithelial cells and transactivates human papillomavirus gene expression. J. Virol. 68: 1173-1178, 1994
Popescu, N., Chen, M., Simpson, S., Solinas, S., and DiPaolo, J.A. A Burkitt lymphoma cell line with integrated Epstein-Barr virusat a stable chromosome modification site. Viral. 195: 248-251, 1993
DiPaolo, J.A., Popescu, M, M., Zimonjic, D., Bornean, Z., and Lusso, P. Interaction of human papillomavirus (HPV) and HIV-1 in HPV-immortalized or tumorigenic cervical cells. Proc. Amer. Assoc. For Cancer Research 34:543, 1993
Zhang, X., Hernandez, M.R., Chen, M.C, and Erickson-Lamy, K.A. Further characterization of muscarinic receptor subtype mRNA in the human ciliary muscle. Investigative Ophthal. And Visual Sci. 32:1200, 1992
Colombian, S., Ablashi, D., Chen, M., DiPaolo, J., Biberfeld, P., and Gallo, R. A new simian herpesvirus contributes substantially to the establishment of B-cell lymphoma in immunodeficiency monkey. Vth International Symposium on Epstein-Barr virus and Associated Diseases VI: 21, 1992
DiPaolo, J.A., Chen, M.C., Corbellino, M., and Ablashi, D.V. Human herpes virus (HHV-6) increases expression of human papilloma (HPV) genes in malignant and non-malignant cervical cells. proc. Amer. Assoc. for Cancer Research 33:392, 1992
Chen, M., Popescu, N., Woolworth, C., Berneman, A., Corbellino, M., Lusso, P., Ablashi, D.V., and DiPaolo, J.A. relationship of human papilloma virus and human herpes virus 6 to cervical neoplasia. The third meeting on the molecular basis of human cancer 51, 1992
Erickson-Lamy, K.A., Chen, M.C. and Hernandez., M.R. Expression of muscarinic receptor mRNA in cultured ciliary muscle cells. Investigative Ophthal. And Visual Sci. 32:833, 1991
French, C.K., Simon, S.L., Chen, M.C., Ekland, S.M., Klotz,. L.C., Vaccaro, K.K., and Savitt, E.D. DNA Probe Diagnosis ofPeriodontal Disease, Chapter 10, 241-263 in Nucleic Acid and Monoclonal Antibody Probes, Application in Diagnostic Microbiology. Maecell Dekker, Inc. New York, 1989
French, C.K., Savitt, E.D., Simon, S.L., Eklund, S.M., Chen, M.C., Klotz, L.C., and Vaccaro, KK. DNA probe detection of periodontal pathogens. Oral microbiology And Immunol. 1:58-62, 1986
Savitt, E.D., Chen, M.C., Vaccaro, K.K., Dzink, J., Chen, P., and Eklund, S.L. Detection of A. Actinomycetemcomitans in plaque by RNA probes. J. Dental Research 65:1648, 1986
Chen, M.C., Chen, P., and Klutz, L.C. use of DNA and RNA probes for the detection of pathogenic bacteria in human oral diseases. Amer. Soc. Microbiol. 86:95, 1986
Ratzkin, B., Lee, S.G., Schlenk, W.J., Roychoudhury, R., Chen, M.C., Hamilton, T.A., and Hung, P.P. Expression in E.coli of biologically active enzyme by a DNA sequence coding for human plasminogen activator, urokinase. Proc. Natl Acad. Sci. (USA) 78:3313-3317, 1981
Lee, S.G., Stowell, C., Hoppe, C., See, Y.S., Chan, S.K., Chen, M.C., and Hung, P.P. Biochemical characterization of urokinase from human fetal kidney cells. In Progress in Fibrinolysis. Volume V, Chapter VI 38-43, 1981
Chen, M.C., Lebowitz, J., and Salzman, N.P. Hind D restriction mapping of unpaired regions in Simian virus 40 superhelical DNA I: consideration regarding structure-function relationships. J. Virol. 18:211-217, 1976
Leibowitz, J., Garon, C.F., Chen, M.C., and Salzman, N.P. chemical modification of Simian virus 40 DNA by reaction with water soluble carbodiimide. J. Virol. 18: 205-210, 1976
Chen, M.C., Berkenmeier, E., and Salzman, N.P. Simian virus 40 DNA replication: characterization of a gap at the DNA termination site. Cold Spring Harbor Tumor Virus Symposia 37, 1975
Kito, G., Chaudhuri, K., Gonenne, A., Chen, M.C., and Lebowitz, J. Characterization of chemical modification of superhelical PM 2 DNA I with MC carbodiimide. Biophysical J. 15:96, 1975
Chen, M.C., Chang, K.S., and Salzman, N.P., Studies of polyoma virus DNA: cleavage map of polyoma virus genome. J. Virol.15:191-198, 1975
Salzman, N.P., Lebowitz, J., Chen, M.C., Kasselberg, A.G., and Garon, C.F. Properties of SV 40 DNA molecules and mapping unpaired regions in SV 40 DNA I. Symposia on Quantitative Biology 39:209-218, 1974
Chen, M.C., Hutchinson III, C.A., and Edgell M.H. Isolation and genetic localization of three Phi X 174 promoter regions. Nature New Biology 243_233-236, 1973
Chen, M.C., Bacteriophage Phi X 174: Genetic recombination, direction of DNA synthesis and localization of promoters. Ph.D. Dissertation. University of North Carolina at Chapel Hill, School of Medicine, 1972
Chen M.C., Hutchinson III, C.A., and Edgell, m.H. In vitro synthesis of infective Phi X 174 recombinant DNA. Cold Spring Harbor Bacteriophage Symposia 106, 1971
Chen, M.C. Dual infection of Simian virus 40 and human adenovirus type 12 in Taiwan monkey kidney cell. Master of Science Thesis. National Taiwan University, School of Medicine, 1967
Hsieh, H.C., Chen, M.C., and Lin, F.M. Studies of the chronic infection of Salmonella typhimurium in mice. J. Formosan Med. Assoc. 63:598, 1964
Liao, T.H. Hsieh, H.C., Chen, M.C. Studies on the isolation of thiamine decomposing bacteria. I. On the aerobic thiamine decomposing bacteria isolated from Taiwan. J. Formosan Med. Assoc. 63:595, 1963

▲Michael C. Chen Books▲

Nucleic acid and monoclonal antibody Probes, Applications in Diagnostic Microbiology Published by Marcel Dekker, Inc, New Yorkand Basel, 1989 Edited by Bala Swaminathan, Gyan Prakash In Chapter 10: DNA Probe Diagnosis of Periodontal Disease.
Cynthia K French, Susanne L Simon, Michael C. Chen, Suzanne M. Eklund, Lynn C Klotz and Karen K. Vaccaro.
Progress in Fibrinolysis. Volume V, 1981 Biochemical characterization of urokinase from human fetal kidney cells. Lee, S.G.,
Stowell,C, Hoppe, C, See,Y.S, Chan, S.K., Chen, M.C. and Hung, P.P

▲Michael C. Chen Sports Achievements▲

Michael C. Chen Washington Area Chinese Tennis Association (WACTA) Tournament
1994 Men’s 3.5 level Single 1st place
1994 Men’s Double C group 1st place
1995 Men’s 4.0 level Single 1st place
1995 Men’s 4.0 level Double 1st place
1997 Men’s 4.0 level Double 1st place
1998 Men’s 4.0 level Double 1st place
1999 Men’s 4.0 level Double 1st place
2004 Men’s 4.0 level Double 1st place

Michael Chen Gaithersburg City Senior Open Tennis Tournament
2001 Mix Double 1st place
2002 Mix Double 1st place

Michael C Chen US Eastern Region Taiwanese Softball Association
1974 Softball Tournament at Washington DC 1st place
1975 Softball Tournament at New Jersey 1st place
1976 Softball Tournament at New York City 1st place

Contents

Foreword
Introduction
Early Childhood
Beginning School
Tiger Stepmother’s Hard Labor Camp at Home
Religious Upbringing and Chinese Philosophy
Dawn’s Early Light and Sunset Red
Eye on the Prize
The American Dream
The Long March
To the Future Generation

Additional Materials
In Memory of Pearl Chen
Pearl Chen Obituary
Pearl and Michael Chen’s Professional Achievements
Pearl M. Chen Professional Experience and Recognition
Pearl M. Chen Patents
Pearl M. Chen Publications
Michael C. Chen Professional Experience and Recognition
Michael C. Chen Patents
Michael C. Chen Publication
Michael C. Chen Books
Michael C. Chen Sports Achievements
My Ancestry
Family Tree

Afterword
Family Photos