Endophthalmitis

This book describes the clinical presentations, diagnostic techniques, microbial pathogens, and antibiotic therapies for various types of endophthalmitis. Each chapter is written by experts in the field with the practicing clinician in mind. Endophthalmitis covers all of the above-mentioned settings and provides the practitioner with the latest guidelines for diagnosing and treating this vision-threatening infection.

Endophthalmitis is one of the most devastating types of eye infections, and most often occurs after eye surgery, an intravitreal injection, or ocular trauma. Endophthalmitis may also occur in eyes with severe keratitis, a glaucoma filtering bleb, or an indwelling ocular device such as a keratoprosthesis, or it may result from spread of organisms to the eye during bacteremia and fungemia. The diagnosis of endophthalmitis may be readily apparent, as in most cases of acute endophthalmitis, or less obvious, as in many cases of subacute or chronic endophthalmitis. In all cases, timely diagnosis and appropriate therapy influence visual outcome.

Marlene L. Durand, MD, is a Consultant in Infectious Diseases at Massachusetts Eye and Ear Infirmary, where she has been Director of the Infectious Disease Service since 1997. She is an Associate Professor in both Medicine (Infectious Disease Unit) and Ophthalmology at Harvard Medical School. Dr. Durand holds board certifications in Internal Medicine and Infectious Diseases. Her clinical and research interests are eye infections, including infectious causes of uveitis, keratitis, and endophthalmitis, and otolaryngeal infections. She is a Fellow of the Infectious Disease Society of America. She has repeatedly appeared inBest Doctors and Best Doctors in America and is the author of more than 90 peer-reviewed articles, book chapters, and reviews.

Joan W. Miller, MD, FARVO, is Henry Willard Williams Professor of Ophthalmology and Chair of the Department of Ophthalmology at Harvard Medical School. She also serves as Chief of Ophthalmology at both Massachusetts Eye and Ear and Massachusetts General Hospital. An internationally recognized expert on retinal disorders, Dr. Miller is credited with co-developing verteporfin photodynamic therapy (PDT), the first pharmacologic treatment for retinal disease, and co-discovering the role of vascular endothelial growth factor (VEGF) in eye disease. Her research also demonstrated the therapeutic potential of VEGF inhibitors in eye disease, forming the scientific basis of antiangiogenic treatments for age-related macular degeneration (AMD), diabetic retinopathy, and related conditions. She has authored more than 200 peer-reviewed research articles, reviews, and book chapters. Additionally, she has been a member of the investigative team for 20 clinical trial reports and has edited several textbooks, including the 3^rd edition of Albert and Jakobiec’s Principles and Practice of Ophthalmology. Her numerous honors include the 2014 Antonio Champalimaud Vision Award, the highest distinction in ophthalmology and visual science, and the 2015 Mildred Weisenfeld Award for Excellence in Ophthalmology.

Lucy Hwa-Yue Young, MD, PhD, FACS, is a Surgeon in Ophthalmology at Massachusetts Eye and Ear, and Associate Surgeon to the Affiliate Staff at Brigham and Women’s Hospital. Her clinical interests comprise various vitreoretinal conditions, including trauma-related complications, infectious retinitis, diabetic retinopathy, and AMD. A foremost expert in the diagnosis and management of uveitis and infectious retinitis, Dr. Young receives referrals from retina specialists throughout New England and delivers lectures both nationally and internationally. A Senior Scientist at Mass. Eye and Ear and Associate Professor of Ophthalmology at Harvard Medical School, she is conducting several lines of investigation to improve the diagnosis and treatment of ocular toxoplasmosis. Dr. Young has authored more than 90 peer-reviewed research articles, reviews, and book chapters. Additionally, she has been a member of the investigative team for 25 clinical trial reports. Since 2002 she has served as director of the Lancaster Course in Ophthalmology, which is the world’s oldest and largest ophthalmic educational course and draws ophthalmology practitioners and trainees worldwide. She has received multiple honors for teaching and mentoring, and has been recognized in America’s Top Ophthalmologists,Best Doctors in America, and Castle Connolly Top Docs.