Small Molecule Medicinal Chemistry: Strategies And Technologies

Medicinal chemists Czechtizky and Hamley present 16 chapters by scientists from the US and Europe, who explain the identification and development of small molecule drugs. They address access to new collections, including strategies for compound library enhancement, the European Lead Factory project, and new business models for compound acquisition and sharing; access to new chemistries, including new advances in diversity-oriented synthesis, solid-phase combinatorial chemistry, and applications of multicomponent reaction chemistry in small molecule drug discovery; screening strategies, with discussion of computational techniques to support hit triage, fragment-based drug discovery, virtual screening, and phenotypic screening; technologies for medicinal chemistry optimization, including advances in the understanding of drug properties, automated solution phase library production, and ADME (absorption, distribution, metabolism, and excretion) profiling; and medicinal chemistry related to the role of natural products in drug discovery (with examples of marketed drugs), peptidomimetics, and in vivo imaging of drug action. Annotation c2016 Ringgold, Inc., Portland, OR (protoview.com)

Werngard Czechtizky is the Head of Medicinal Chemistry of the German Hub of Sanofi, based in Frankfurt, Germany. She has wide experience in lead generation and lead optimization for central nervous system, cardiovascular and diabetes targets, and her teams have been responsible for a number of leads and clinical candidates in these areas over the last years. She was educated at ETH Zurich and Harvard University, USA.

Peter Hamley is the global head of External Innovation and Sourcing for chemistry, computational chemistry, and screening technologies at Sanofi, based in Frankfurt, Germany. He spent ten years at AstraZeneca in the United Kingdom, and then moved to Sanofi as a medicinal chemistry leader, building their automated chemistry capabilities and natural product technology. He was educated at Imperial College, London, the University of Cambridge and the University of Pennsylvania.