Animal Lectins

Introduces Groundbreaking Approaches for Assessing Lectin Function
Lectins and their ligands are under quite a heavy microscope due to their potential applications to pharmacology, immunology, cancer therapy, and agriculture. With growing interest in the glycobiology field, the body of research related to lectin roles has grown at an explosive rate, particularly in the past 20 years. Animal Lectins: A Functional View presents the most up-to-date analysis of these carbohydrate-binding, and potentially lifesaving, proteins in one comprehensive volume.

This standard-setting resource presents new insights into the biological roles of most animal lectins, including their function in infection prevention through innate immunity. It also discusses such lectin behaviors as:



Glycoprotein folding


Sorting and targeting


Cell adhesion


Embryogenesis


Cell-cell interactions and signaling


Describes the Structural Basis of Protein-Carbohydrate Interactions
Under the editorial guidance of two leading protein chemistry experts and with contributions from well-recognized field authorities, this book logically and systematically discusses both intracellular and extracellular lectin functions. It is an essential springboard for future field research and a clear and concise knowledge base that glycobiology, biochemistry, and immunology researchers cannot afford to be without.

INTRODUCTION
Introduction to Animal Lectins, G.R. Vasta and H. Ahmed
MODERN APPROACHES FOR ASSESSING LECTIN FUNCTION
Structural Aspects of Lectin–Ligand Interactions, M.A. Bianchet, H. Ahmed, G.R. Vasta, and L.M. Amzel
Thermodynamic Approaches to the Study of Affinity of Clustered Carbohydrate Epitopes in Galectin–Glycoconjugate Interactions, T.K. Dam and C.F. Brewer
Deciphering Lectin Ligands through Glycan Arrays, D.F. Smith and R.D. Cummings
Chromatography and Related Approaches for Qualitative and Quantitative Analyses of Lectin Specificity, J. Hirabayashi
Analysis of Whole-Genome and Other Data Resources to Characterize the Molecular, Structural, and Evolutionary Diversity of C-Lectins and Discover New Genes, A.N. Zelensky and J.E. Gready
Animal Models for Assessing the Biological Roles of Lectins, H. Ahmed, G.A. Rabinovich, S.S. Jackson, M. Salatino, K. Saito, G. Bianco, S. Tasumi, S.-J. Du, and G.R. Vasta
GLYCOPROTEIN FOLDING, SORTING AND SECRETION, TARGETING, DEGRADATION, AND CLEARANCE
Calreticulin and Calnexin as Chaperones in Glycoprotein Folding, J.J. Caramelo and A.J. Parodi
Role of L-Type Lectins in Glycoprotein Sorting and Trafficking, B. Nyfeler, M.W. Wendeler, and H.-P. Hauri
P-Type Lectins and Lysosomal Enzyme Targeting, N.M. Dahms, L.J. Olson, and J.-J.P. Kim
M-Type Lectins as Novel Components of Secretory Pathways, N. Hosokawa and K. Nagata
Functional Aspects of the Hyaluronan and Chondroitin Sulfate Receptors, E.N. Harris and P.H. Weigel
CELL ADHESION AND CELL SURFACE LATTICE FORMATION
Galectin-3 and Cancer, Y. Wang, V. Balan, and A. Raz
Myelin-Associated Glycoprotein (Siglec-4): A Nervous System Lectin That Regulates Axon–Myelin Stability and Axon Regeneration, R.L. Schnaar and N.R. Mehta
Hyaluronan-Binding Proteoglycans, E.N. Harris and P.H. Weigel
Roles of Coral Lectins in Morphological Change of Zooxanthellae, H. Kamiya, M. Jimbo, K. Koike, and R. Sakai
CELL–CELL INTERACTIONS, SIGNALING, AND TRANSPORT
Siglecs: Roles in Cell–Cell Interactions and Signaling, C.O. and P.R. Crocker
Signaling through the Fungal b-Glucan Receptor Dectin-1, A.M. Kerrigan, K.M. Dennehy, and G.D. Brown
CD22: A Regulator of B Cell Survival and Signal Transduction, S.H. Smith and T.F. Tedder
Galectins and Integrins in Pre-B Cell Development, M. Espeli, L. Gauthier, S. Mancini, F. Mourcin, B. Rossi, and C. Schiff
Golgi N-Glycan Processing and Galectin Functions, K.S. Lau, I.R. Nabi, M. Demetriou, and J.W. Dennis
RECOGNITION AND EFFECTOR FUNCTIONS IN INNATE IMMUNITY
Mannan-Binding Lectin Polymorphisms and Infectious Diseases, M. Møller-Kristensen, S. Thiel, and J.C. Jensenius
Immunoregulatory Roles of Lung Surfactant Proteins A and D, N. Palaniyar, G.L. Sorensen, and U. Holmskov
C-Type Lectin Receptors on Dendritic Cells, Y. van Kooyk
Structural and Functional Roles of C-type Lectin Receptors on Natural Killer Cells, N. Dimasi
Activation of Lepidopteran Insect Innate Immune Responses by C-type Immulectins, X.-Q. Yu and M.R. Kanost

Galectins as Novel Regulators of Immune Cell Homeostasis and Inflammation, G. A. Rabinovich, M.A. Toscano, J.M. Ilarregui, and L.G. Baum
Interactions of Galectins with Leukocytes, S.R. Stowell and R.D. Cummings
Regulation of Immune Responses by Galectin-3, D. K. Hsu and F.-T. Liu
X-Lectins: A New Family with Homology to the Xenopus laevis Oocyte Lectin XL-35, J.K. Lee and M. Pierce
F-Type Lectins: A New Family of Recognition Factors, G.R. Vasta, E.W. Odom, M.A. Bianchet, L.M. Amzel, K. Saito, and H. Ahmed
Biology of FREPs: Diversified Lectins with Fibrinogen-Related Domains from Freshwater Snail Biomphalaria glabrata, B.A. Stout, C.M. Adema, S.-M. Zhang, and E.S. Loker
Lectins in Sand Fly–Leishmania Interactions, S. Kamhawi and J.G. Valenzuela
Ficolins: The Structural Basis for Recognition Plasticity, M. Matsushita, Y. Endo, and T. Fujita
Hemolytic Lectin in Marine Invertebrates, T. Hatakeyama
Structure–Function Relationship in Mammalian Chitinase-Like Lectins, S. Morroll, S. Turner, and F.H. Falcone
Index