In this completely updated and expanded edition of a classic bench manual, hands-on experts take advantage of the latest advances in ribozyme, DNAzyme, and RNA interference technologies to describe i
RNA interference has become a key method in the suppression of gene expression and the development of therapeutic agents, yet there is still the problem of delivery, stability, and the danger of off-
RNA Interference: Challenges and Therapeutic Opportunities provides readers with recent advances in siRNA design, delivery, targeting and methods to minimize siRNA’s unwanted effects. Preclinical and
These articles address the most current methods for drug target discovery and validation and explore how recent discoveries in molecular mechanisms of human pathology impact work in the laboratory and
These articles address the practical side of the most current methods for efficient translation of discovered targets onto real drugs, with specific emphasis on siRNAs, antisense oligonucleotides and
Central to the synthesis of proteins, the performance of catalysis, and many other physiological processes, the aberrant expression of which can be linked to human diseases including cancers, RNA has
