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布瑞納證明訊息核糖核酸（mRNA）的存在，而mRNA的重要性歷久彌新，拜新冠肺炎疫苗的創新突破所賜，現在連一般大眾也能很自然地隨口說出「mRNA」這個字眼。西德尼．布瑞納（Sydney Brenner，1927-2019）是2002年諾貝爾生醫獎的獲獎者。他參與解開基因編碼、證明訊息核糖核酸（mRNA）的存在、線蟲的全基因體解析等重大生物學事件，同時建立發育遺傳學的「線蟲模型」，對多細胞生物的「細胞命運」（cell fate）研究，打下至為關鍵的基礎。多位重量級之生物學家甚至認為，布瑞納這些突破性的發現與創見，使其足可與孟德爾、達爾文等人並列，可被譽為史上最偉大的生物學家之一。本書綜觀布瑞納的大半生，從他童年時期在父親鞋店後方的房間做實驗，到成為英國重量級醫學研究所的主任，其間不論學思歷程與生活點滴，都有生動活潑地描繪與自剖。本書內容以布瑞納的錄影訪談為基礎，除了基因、遺傳等專業觀念的論證外，字裡行間處處展現出布瑞納的獨到見解、機智幽默、科學堅毅等精神。當然，絕對不乏他廣受大眾喜愛的「反傳統」獨到思維。閱讀本書，你不但可以了解這位「基因巨擘」的科學人生和風範，更能與其共同親炙從事科學之純真，保證深獲啟迪。【布瑞納的金句】•只有閱讀並不夠，但有時思考也不夠，因為最終的重點在於實作。因此，實作才是科學界真實的意義所在。•在生物學中『別擔心假說』非常重要──相信為達成某事，總是會有可行的方法，那麼當下你就不需要太擔心，而能實在地繼續做事。•我認為，那些不受標準方法牽引的外行人，才能夠以不同的方式看待事物，並且邁出新的步伐。……這就是無知取勝之處！•選擇實驗對象依然是生物學中一件最重要的事，我認為也是從事創新工作最好的方法之一。……你需要做的，是要找到哪個是可以透過實驗解決問題的最佳系統。•我親手進行這所有的實驗。原因很簡單，因為我喜歡培養生物。我一直都覺得非常有趣的事，就是把研究的計畫做到其他人可以接手的階段，並開發所有各式相關的技術（little tricks）。•我一直都覺得推動科學向前發展的最佳人選，就是科學領域之外的人。也許對文化來說也是如此。移民永遠是探索新發現的最佳人選！所以當有人對我說：『你們實驗室的組織是什麼性質？』我只想得到一個答案，那就是：『不被束縛的一群人！』•我在1979年成為（MRC實驗室）主任。回顧起來，我認為那是個天大的錯誤，擔任這種職位的人

A specialist in cell and developmental biology, Wolpert (emeritus, U. College, London) describes for non-specialists embryonic development, that is, the processes by which a single cell--the fertilize

Everything about our existence-movement and memory, imagination and reproduction, birth, and ultimately death-is governed by our cells. They are the basis of all life in the universe, from bacteria t

In Lewis Carroll's Through the Looking-Glass, the White Queen tells Alice that to believe in a wildly improbable fact she simply needs to "draw a long breath and shut [her] eyes." Alice finds this ad

Everything about our existence--movement and memory, imagination and reproduction, birth and, ultimately, death--is governed by our cells. They are the basis of all life in the universe, from the tin

Why do 70 percent of Americans believe in angels, while others are convinced that they were abducted by aliens? What makes people believe in improbable things when all the evidence points to the con

How different are men and women, really? Controversy surrounds the question and makes uncovering the answers?based in evolution, genetics, and biology?increasingly difficult. Still, significant differ

How do we move, think and remember? Why do we get ill, age and die? Distinguished biologist Lewis Wolpert explains how cells provide the answers to the fundamental questions about our lives.Cell are t

He looks at belief's psychological basis and its possible evolutionary origins in physical cause and effect. And he asks whether it is possible to live without belief at all, or whether it is a necess

'An excellent book, the most objective short account I know of all the various approaches to depression.' Anthony Storr Several years ago, Lewis Wolpert had a severe episode of depression.

How is it that nobody--except maybe scientists--sees science for what it is? In this entertaining and provocative book, Lewis Wolpert draws on the entire history of science, from Thales of Miletus to

From a single cell--a fertilized egg--comes an elephant, a fly, or a human. How does this astonishing feat happen? How does the egg "know" what to become? How does it divide into the different cells,

Now he enters the gender debate, starting with his argument that men are fundamentally modified females - if the genes present at fertilisation did not do their job properly, we would all be women - a

胚胎變，變，變！ 我是誰？從哪裡來？ 深邃、幽暗中，精子奮力地與卵相逢， 從一個結合的受精卵，複製、分裂成二個、四個、八個…… 冥冥中，彷彿已有定序，相同的細胞走向不同的歸途， 肌肉、骨骼、神經、器官、系統，於是漸漸成形， 脫離溫暖如海洋的母體後，我成為我。單單一個受精卵，如何繁衍出上億個細胞，並且分化成結構複雜、功能殊異的組織、器官和系統，最後成為一個獨立的生命體？對「胚胎發育」的研

How does a single cell develop into myriad different specialized cell types, control the organization of these different cells into tissues and organs, and ultimately form an unimaginably complex livi

Ancient Greece was the birthplace of science, which developed in the Hellenized culture of ancient Rome. This book, written by seventeen international experts, examines the role and achievement of sci

Depression is a major cause of morbidity throughout the world. Given that between 8 and 12% of the population (in most countries) will suffer from depression at some point in their lives, it is clear