Applying the Basic Sciences to Clinical Medicine
Part 1.Approach to Learning Pathology
Part 2.Approach to Disease
Part 3.Approach to Reading
Fifty Case Scenarios
Listing of Cases
Listing by Case Number
Listing by Disorder（Alphabetical）
Acute hepatitis: The influx of acute inflammatory cells,which may follow or precede hepatocyte necrosis.The morphologic changes in both acute and chronic hepatitis are common to the hepatitis viruses and can be mimicked by drug reactions.
Chronic hepatitis: It can be due to numerous causes,all of which result in hepatic inflammation and necrosis for at least 6 months,but without the nodular regeneration and architectural distortion of cirrhosis.
Hepatic steatosis: Also known as"fatty liver,"this entity commonly is due to alcohol ingestion but also can be due to many other causes of altered lipid metabolism(diabetes,obesity,glucocorticoid use,total parenteral nutrition,some drug reactions),resulting in the accumulation of fat first in cytoplasmic microvesicles in the hepatocyte.Later,the vacuoles coalesce into macrovesicles,compressing and displacing the nucleus so that the hepatocyte resembles a lipocyte.Grossly,the liver becomes enlarged with a yellow,greasy appearance.Steatosis is usually reversible with discontinuation of the underlying cause,but it may lead to the develop ment of fibrosis around the central veins and sinusoids and ultimately to cirrhosis.