'I had the good fortune to behold for the first time that fantastic ending of the growing axon. In my sections of the spinal cord of the three day chick embryo, this ending appeared as a concentration of protoplasm of conical form, endowed with amoeboid movements. It could be compared with a living battering ram, soft and flexible, which advances, pushing aside mechanically the obstacles which it finds in its path, until it reaches the region of its peripheral termination. This curious terminal club, I christened the growth cone.' (Santiago Ramón y Cajal, Recollections of My Life, 1937). In Neuronal Growth Cones, Phillip Gordon-Weeks presents the molecular biology of the behavior of growth cones. The book covers the basic morphology and behavior of growth cones, motility and neurite extension via the growth cone cytoskeleton, pathfinding, intracellular signalling, and synaptogenesis. It is the first detailed, critical analysis of all aspects of growth cone biology.
Kevin doesn't mean to make trouble when he lies. He's just really good at it, and it makes life so much easier. But as his lies pile up, he finds himself in big—and funny—trouble with his friends, fam
At the core of Swedenborg’s thought is the understanding that our purpose in this life is to progress spiritually—to learn, to grow, to do good works, and, ultimately, to allow as much of God’s lov
Thomas William Coke, the Norfolk landlord, was a legend in his own lifetime as a man dedicated to progressive reforms in agriculture and to the improvement of the conditions of his tenants. His Holkham estate was set up as a fine example to be followed by farmers and landlords alike. This book deals with the work of both Thomas William Coke and his son, their agents and their tenants at Holkham through the nineteenth century and into the early years of the twentieth. It shows how far even the most dynamic landlord needed a progressive tenantry and how far the tenantry relied on the landlord for the provision of good farm buildings and other capital expenditure. The building work of the estate in the erection of both farms and cottages is studied in detail. The aim of the book is to show life and work on the Holkham estate both from the landlord's point of view and from that of the tenant farmer and cottager.
This innovative new publication provides a valuable resource for all those involved in the care and rehabilitation of people with disability. A unique feature of the book is its integration of the concepts and principles of rehabilitation with good clinical practice. It encompasses a wealth of material from a broad range of perspectives including social and educational aspects, good management practice, audit evaluation research and statistics. It deals with physical and intellectual disability and spans the range from childhood disability to disablement and rehabilitation in later life and old age. This broad-based but scientifically informed book recognises that breadth of expertise is needed to adequately assess the needs of people with disability and to establish appropriate strategies for their treatment. The volume will be an essential text for MSc students of rehabilitation studies and for other health care professionals.
Many economic problems are also ethical problems: should we value economic equality? how much should we care about preserving the environment? how should medical resources be divided between saving life and enhancing life? This book examines some of the practical issues that lie between economics and ethics, and shows how utility theory can contribute to ethics. John Broome's work has, unusually, combined sophisticated economic and philosophical expertise, and Ethics Out of Economics brings together some of his most important essays, augmented with an updated introduction. The first group of essays deals with the relation between preference and value, the second with various questions about the formal structure of good, and the concluding section with the value of life. This work is of interest and importance for both economists and philosophers, and shows powerfully how economic methods can contribute to moral philosophy.
For hundreds of years, we thought we knew what happened during Jesus' last days. Holy Thursday, Good Friday and Easter Sunday are not only observed by Christians around the world, but are also recognized in calendars and by non-practitioners as commemorating the true timeline of events in the life of Christ. But apparent inconsistencies in the gospel accounts of Jesus' final week have puzzled Bible scholars for centuries. In The Mystery of the Last Supper, Colin Humphreys uses science to reveal the truth about Jesus' final days. Reconciling conflicting Gospel accounts and scientific evidence, Humphreys reveals the exact date of the Last Supper in a definitive new timeline of Holy Week.
Rapid urbanization and political liberalization is changing the nature of African politics and societies. This book develops a framework for the study of democracy and development that emphasizes informal institutions and the politics of belonging in the context of daily life, in contrast to the formal and electoral paradigms that dominate the social sciences. Based on fifteen months of field research including ethnographic observation, focus group interviews, and original quantitative survey analysis in Ghana, this book intervenes in major debates about public goods provision, civic participation, ethnic politics and democratization, and the future of urban sustainability in a rapidly changing world. By developing new understandings of democracy, as well as providing novel explanations for good governance and development in poor urban neighborhoods, the book transcends the narrative of a failing and corrupt Africa and charts a new way forward for the study of democracy and development
The environmental crisis creates an unprecedented moral predicament: how to be a good person when our collective and individual actions contribute to immeasurable devastation and suffering. Drawing on an extraordinary range of sources from philosophy, political theory, global religion, ecology, and contemporary spirituality, Roger S. Gottlieb explores the ethical ambiguities, challenges, and opportunities we face. Engagingly written, intellectually rigorous, and forcefully argued, this volume investigates the moral value of nature; the possibility of an 'ecological' democracy; how we treat animals; the demands and limits of individual responsibility and collective political change; contemporary ambiguities of rationality; and how to face environmental despair. In Morality and the Environmental Crisis, Gottlieb combines compassion for the difficulties of contemporary moral life with an unflinching ethical commitment to awareness and action.
Friedrich Nietzsche (1844–1900) remains one of the most challenging, influential and controversial figures in the history of philosophy. The New Cambridge Companion to Nietzsche provides a comprehensive and up-to-date guide to his most difficult ideas, including the will to power and the affirmation of life, as well as his treatment of truth, science, art and history. An accessible introduction sets out the nineteenth-century background of Nietzsche's life and work. Individual chapters are devoted to significant texts such as The Birth of Tragedy, Thus Spoke Zarathustra, Beyond Good and Evil and On the Genealogy of Morality. Other chapters explore major influences such as Wagner and Schopenhauer, as well as examining Nietzsche's reception and investigating his enduring and often divisive legacy. The volume will be valuable for readers seeking to enhance their understanding of Nietzsche's philosophy and of his role in the development of Western thought.
There's a difference between falling and letting go.Lauren has a good life: decent grades, great friends, and a boyfriend every girl lusts after. So why is she so unhappy? It takes the arrival of Eva
Even good things can become idols if we give them central importance in our lives. Having children changes everything, and as mothers, we risk looking for life, purpose and meaning in motherhood. Whil
In SelfLess, popular speaker Megan Fate Marshman exposes the source of self-limiting beliefs that create needless striving to be good enough and points to powerful truths that can transform life into
The story of Joseph is more than just the story of one man. Baucham explores the redemptive-historical significance of Joseph’s amazing life, highlighting God’s ultimate plan to save his people in and
Motivational self-help advice from President Donald Trump, covering everything from leadership and self-confidence to how to succeed in business.President Donald Trump knows about living the good life
An inside look at the secretive world of elite philanthropists--and how they're quietly wielding ever more power to shape American life in ways both good and bad. While media attention focuses on famo
Resign yourself to the great resignation and just say bye. BYE, I Quit is a blend of satire and encouragement to help you find meaning and humor to get through the workday. If you have had a recent epiphany about quitting your job or know someone who has, this fully illustrated, meme-worthy guidebook offers the inspiration needed to keep your chin up and tap into what really matters in life. (Spoiler: it's not your job). Sample entries include: Affirmations that you are more than just your jobMeditations to keep you focused during your 8 a.m. meetingA flowchart to determine if you should send that passive-aggressive emailMantras for when you're burnt out Humorous illustrations of all the little things that bug you at work (seafood in the microwave, anyone?)Step-by-step guides for getting motivated or having a really good FridayInspirational quotes to help you connect to your true passion and purposeEqual parts hopeful and snarky--okay, fine, it's actually mostly snarky--BYE, I Quit is
Pastor Rob Bentz helps individuals and small groups grasp the importance of the local church for the Christian life through engaging anecdotes, powerful reflections on Scripture, and instructive lesso
This carefully selected collection of sermons acquaints readers with the life and ministry of famed preacher Dr. Martyn Lloyd-Jones, explaining each message’s historical context and relevance for the
We never saw it coming. For the first time in her life sixteen year old Brenda Kay is finally settled, and calls Turney, Texas, home. She has a job. Life is good Until a surprise visit from he
