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This book covers recent developments of magnetic nanoparticles (MNPs) in nanomedicine, including in vivo and in vitro theranostics (therapy and diagnostics). The book is divided into five sections. Section I provides readers with the fundamental theories and principles of magnetic materials, the synthesis and surface functionalization strategies of MNPs, and the standard techniques for characterizing physicochemical properties of MNPs. Section II reviews MNP-based therapies such as magnetic hyperthermia therapy, drug/gene delivery, and magnetic neurostimulation. Sections III and IV cover MNP-based in vitro and in vivo disease diagnosis, respectively, including techniques such as magnetoresistive (MR), nuclear magnetic resonance (NMR), magnetic particle spectroscopy (MPS) biosensing platforms, magnetic resonance imaging (MRI), and magnetic particle imaging (MPI). Section V addresses biocompatibility and safety issues in applying MNPs to in vivo biomedical applications, including coverage of the toxicity of MNPs to human tissues, the immune responses of the human body to these particles, as well as blood circulation time of MNPs.
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