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Rather than simply revise the material presented in the last edition, Lange (The Rockefeller U.), Lundblad (The Salk Institute for Biological Sciences) and Blackburn (U. of California at San Francisco) instead present an entirely new compilation of 17 essays for this monograph on telomeres. After a historical treatise on the field, the general attributes and telomeres and telomerases and the relation of telomere biology to human health are discussed in chapters on the telomerase ribonucleoprotein particle, telomerase biochemistry and biogenesis, telomerase and human cancer, modeling cancer and aging in the telomerase-deficient mouse, telomerase deficiency and human disease, telomerase-independent maintenance of mammalian telomeres, telomerase-independent telomere maintenance in yeas, meiotic telomeres, telomere position effect, and telomere structural biology. The remaining material describe telomere biology in the best-studied systems: budding yeast, mammals, Drosophilia, ciliates, plants, and fission yeast. Annotation c2006 Book News, Inc., Portland, OR (booknews.com)
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