HANDBOOK OF DENDRITIC CELLS - BIOLOGY, DISEASES AND THERAPIES 3V SET

This is the most comprehensive handbook on dendritic cells, featuring an introduction by Ralph M. Steinman and written by top experts. In three volumes, it covers all aspects from molecular cell biology to clinical applications, highlighting the role of dendritic cells in fighting cancer, virus infections, and autoimmune diseases.
The first section on cell biology looks at dendritic cell development, circulating cells, T cell priming, Th1 and Th2 decision and CTL priming. A second part on dendritic cells in disease deals with parasites, bacteria, viruses, autoimmunity, allergies, asthma and cancer. The final section on therapeutic applications includes viral infections and antigen delivery.

Manfred B. Lutz grew up in the Black Forest in the Southwest of Germany where he also studied pharmacy in Freiburg (1984 -1989). After his PhD in Immunology with Bruno Kyewski at the German Cancer Research Center in Heidelberg, he first contacted dendritic cells in 1993 when he joined Paola Ricciardi-Castagnoli's lab in Milano, Italy. Since 1996 he works at the Department of Dermatology with Gerold Schuler in Erlangen, where he is currently leading a research group. He became Assistant Professor in 2001.


Nikolaus Romani originates from the Montafon valley, a renowned skiing area in Western Austria. He combined skiing, learning and research at the University of Innsbruck where he obtained his PhD in biology 1983. After two years at the Rockefeller University in Ralph Steinman's laboratory (1987-88) he - together with Gerold Schuler, his co-worker and mentor - helped to make Innsbruck one of the first "dendritic cell strongholds" in the Old World. He became Associate Professor in 1990 and has been involved in dendritic cell research at the Department of Dermatology of "Innsbruck Medical University" ever since.


Alexander Steinkasserer originates from South Tyrol (Northern Italy) and apart from skiing he spent most of his youth on football grounds. He studied biology in Innsbruck (PhD). Afterwards he moved to the Institute of Immunology in Munich (1986-1989) and then to the University of Oxford (1989-1993). Next he went to the Novartis Research Institute in Vienna, were he encountered for the first time dendritic cells (1993-1996). Then he spent two years at the research departments of Immuno-Baxter in Vienna, before he obtained his Professorship at the University of Erlangen were he works since 1998 and heads the Department of Experimental Dermatology.

VOLUME 1.

Preface.

List of Contributors.

PART A: DENDRITIC CELL BIOLOGY.

1. Introduction to some of the Issues and Mysteries Considered in this Book on Dendritic Cells (R. Steinman).

I. Dendritic Cell Development.

2. Bone Marrow Progenitors of Dendritic and Natural Interferon-producing Cells (M. Manz).

3. Growth Factors (H. Strobl, et al.).

4. Transcription Factors: Deciphering the Transcription Factor Network of Dendritic Cell Development (T. Hieronymus & M. Zenke).

II: Sentinel Dendritic Cells in Non-lymphoid Organs.

5. Epidermal Langerhans Cells (N. Romani, et al.).

6. Characterization of Dendritic Cells and other APC in the Eye (J. Stein-Streilein).

7. Toll-like Receptors (H. Hochrein & H. Wagner).

8. C-type Lectins on Dendritic Cells: Antigen Receptors and Modulators of Immune Response (Y. van Kooyk & T. Geijtenbeek).

9. Scavenger Receptors on Dendritic Cells (E. McKenzie, et al.).

10. Production of the Long Pentraxin PTX-3 by Myeloid Dendritic Cells: Linking Celluar and Humoral Innate Immunity (P. Allavena, et al.).

11. Gene Profiling of Dendritic Cells During Host-Pathogen Interactions (M. Foti, et al.).

III: Dendritic Cells in Secondary Lymphoid Organs.

12. Dendritic Cell Subtypes (K. Shortman & J. Villadangos).

IV: Circulating Dendritic Cells and their Precursors.

13. pDC: From Plasmacytoid Dendritic Cell Precursors to Professional Type 1Interferon-producing Cells (Y. Liu, et al.).

14. Monocyte Subsets and their Relation to DCs (B. Senechal, et al.).

V: Dendritic Cell Migration.

15. Steady State Migration of Dendritic Cells in Lymph (G. MacPherson, et al.).

16. Multiple Pathways to Control DC Migration (K. Otero, et al.).

VI: T Cell Activation and Costimulation.

17. Antigen Processing and Presentation: CD1d and NKT Cells (S. van Dommelen, et al.).

18. The Role of Dendritic Cells in T-Cell Activation and Differentiation (F. Sallusto & A. Lanzavecchia).

19. Cytokines Produced by Dendritic Cells (D. Tough).

VOLUME 2.

VII: Th1 and Th2 Decision.

20. The Plasticity of DC Populations in Promoting Th Cell Responses (A. Boonstra, et al.).

21. Microbial Instruction of Dendritic Cells (E. de Jong, et al.).

VIII: CTL Priming and Crosspresentation.

22. Crossprocessing and Crosspresentation (M. Skoberne & N. Bhardwaj).

23. A Systems Biologist's View on Dendritic Cells— Cytotoxic T Lymphocyte Interaction (B. Ludewig & G. Bocharov).

IX: Dendritic Cells Cross-talk with Other Cell Types.

24. Dendritic Cells and Natural Killer Cells (M. Terme & L. Zitvogel).

25. Intercellular Communication via Protein Transfer (M. Wauben).

X: Tolerogenic Dendritic Cells.

26. Differentiation Stages and Subsets of Tolerogenic Dendritic Cells (M. Lutz).

27. Dendritic Cell Manipulation with Biological and Pharmalogical Agents to Induce Regulatory T Cells (L. Adorini & G. Penna).

28. Surface Molecules Involved in the Induction of Tolerance by Dendritic Cells (L. Bonifaz).

29. Interaction Between Dendritic Cells and Apoptotic Cells (A. Larregina & A. Morelli).

30. Pharmacologically Modified Dendritic Cells: A Route to Tolerance-associated Genes (K. Nolan, et al.).

PART B: DENDRITIC CELLS IN DISEASE.

XI: Parasites.

31. Malaria (B. Urban & F. Ndungu).

32. Dendritic Cells in Leishmaniasis: Regulators of Immunity and Tools for New Immune Intervention Strategies (H. Moll).

33. Sentinel and Regulatory Functions of Dendritic Cells in the Immune Response to Toxoplasma Gondii (A. Sher, et al.).

34. Schistosoma (A. MacDonald & E. Pearce).

XII: Bacteria.

35. Dendritic Cells and Immunity to Salmonella (M. Wick).

36. Dendritic Cells in Tubercolosis (U. Schaible & F. Winau).

37. Dendritic Cell-Epithelial Cell Interactions in Response to Intestinal Bacteria (M. Rescigno).

VOLUME 3.

XIII: Viruses.

38. Sleeping with the Enemy: The Insidious Relationship Between Dendritic Cells and Immunodeficiency Viruses (L. Vachot, et al.).

39. Cytomegalovirus Infection of Dendritic Cells (B. Sénéchal & J. Young).

40. Interactions of Hemorrhagic Fever Viruses with Dendritic Cells (S. Pöhlmann).

41. Dendritic Cells in Measles Virus Pathogenesis (M. Abt, et al.).

42. Dendritic Cells and Herpes Simplex Virus Type 1 (A. Prechtel & A. Steinkasserer).

43. Epstein-Barr Virus (C. Münz).

XIV: Fungi.

44. Dendritic Cells in Immunity and Vaccination against Fungi (L. Romani & P. Puccetti).

XV: Autoimmunity.

45. Dendritic Cells in Autoimmune Diseases (A. Mathian, et al.).

XVI: Transplantation.

46. Role of Dendritic Cells in Graft Rejection and Graft-versus-host-Disease (V. Flamand & M. Goldman).

47. Dendritic Cells and Transplantation Tolerance (P. Fairchild, et al.).

48. Dendritic Cells, Immune Regulation and Transplant Tolerance (G. Raimondi & A. Thomson).

XVII: Allergy, Asthma.

49. Nickel Presentation to T Cells in Contact Hypersensivity (H. Weltzien, et al.).

50. Dendritic Cells in Asthma (H. Hammad & B. Lambrecht).

XVIII: Cancer.

51. Dendritic Cells in Human Cancer (C. Carlos & O. Finn).

PART C: THERAPEUTICAL APPLICATION OF DENDRITIC CELLS.

XIX: Cancer.

52. Dendritic Cell Subsets as Targets and Vectors for Vaccination (H. Ueno, et al.).

53. Renal Cell Carcinoma (M. Thurnher, et al.).

XX: Antigen Delivery.

54. Cross Presentation and Loading of Tumor Antigens for Dendritic Cell Vaccination against Cancer (M. Dhodapkar).

55. Nucleic Acid Transfer (N. Schaft, et al.).

Subject Index.